Monohybrid Cross Practice Problems Worksheet

By | November 21, 2025

Are you struggling to understand the principles behind monohybrid crosses? Genetics can be tricky, and mastering monohybrid crosses is fundamental for grasping more complex inheritance patterns. A great way to solidify your knowledge is through practice! That’s why we’ve put together a helpful resource: a Monohybrid Cross Practice Problems Worksheet.

This worksheet is designed to test your understanding of key concepts like dominant and recessive alleles, homozygous and heterozygous genotypes, phenotypes, Punnett squares, and probability. It provides a variety of problems that range in difficulty, allowing you to build confidence as you work through them. Whether you’re a high school biology student, a college student, or simply someone interested in learning more about genetics, this worksheet is a valuable tool for reinforcing your learning.

The problems in the worksheet cover a range of scenarios, from classic pea plant crosses (thanks, Mendel!) to examples involving other organisms and traits. Each problem presents a clear scenario and asks you to determine the genotypes and phenotypes of the parents and offspring, as well as the probability of specific outcomes. By working through these problems, you’ll develop a deeper understanding of how genes are passed from one generation to the next and how to predict the traits of offspring.

Using the worksheet effectively requires understanding the basic terminology. Remember that a **monohybrid cross** involves the inheritance of a single trait determined by a single gene with two alleles. A **gene** is a unit of heredity, and an **allele** is a variant form of a gene. **Dominant alleles** are expressed when present, even if only one copy is present, while **recessive alleles** are only expressed when two copies are present. The **genotype** refers to the genetic makeup of an individual (e.g., AA, Aa, aa), while the **phenotype** refers to the observable traits (e.g., tall, short). A **homozygous** individual has two identical alleles for a trait (e.g., AA or aa), while a **heterozygous** individual has two different alleles (e.g., Aa). Punnett squares are visual tools used to predict the possible genotypes and phenotypes of offspring from a cross.

Don’t just passively read the problems – actively engage with them! Draw Punnett squares, carefully consider the genotypes and phenotypes, and think through the logic of each cross. If you get stuck, review your textbook or online resources. Practice is key to mastering monohybrid crosses, and this worksheet provides the perfect opportunity to hone your skills. To further enhance your learning experience, we have included the answers to all the practice problems below. Use them to check your work, identify areas where you need more practice, and solidify your understanding of monohybrid crosses.

Monohybrid Cross Practice Problems Answer Key

Using the Answer Key

Below you’ll find the answers to the Monohybrid Cross Practice Problems Worksheet. Use these to check your work and understand any mistakes you may have made. Remember that understanding *why* an answer is correct is just as important as getting the correct answer itself. If you’re struggling with a particular problem, revisit the concepts and try to work through it again.

  • Problem 1:
    1. Parental genotypes: BB x bb
    2. Genotype of offspring: All Bb
    3. Phenotype of offspring: All black fur
  • Problem 2:
    1. Parental genotypes: Rr x Rr
    2. Genotypes of offspring: RR, Rr, rr
    3. Phenotypes of offspring: 3 round seeds: 1 wrinkled seeds
  • Problem 3:
    1. Parental genotypes: Tt x tt
    2. Genotypes of offspring: Tt, tt
    3. Phenotypes of offspring: 1 tall: 1 short
  • Problem 4:
    1. Parental genotypes: Hh x hh
    2. Genotypes of offspring: Hh, hh
    3. Phenotypes of offspring: 50% have hitchhiker’s thumb, 50% do not
  • Problem 5:
    1. Parental genotypes: Cc x Cc
    2. Genotypes of offspring: CC, Cc, cc
    3. Phenotypes of offspring: 75% can roll their tongue, 25% cannot
  • Problem 6:
    1. Parental genotypes: Aa x aa
    2. Genotypes of offspring: Aa, aa
    3. Phenotypes of offspring: 50% are albino, 50% are normal pigment
  • Problem 7:
    1. Parental genotypes: Yy x yy
    2. Genotypes of offspring: Yy, yy
    3. Phenotypes of offspring: 50% have yellow seeds, 50% have green seeds.
  • Problem 8:
    1. Parental genotypes: Dd x Dd
    2. Genotypes of offspring: DD, Dd, dd
    3. Phenotypes of offspring: 75% have dimples, 25% do not.
  • Problem 9:
    1. Parental genotypes: Gg x gg
    2. Genotypes of offspring: Gg, gg
    3. Phenotypes of offspring: 50% have a cleft chin, 50% do not
  • Problem 10:
    1. Parental genotypes: Ff x ff
    2. Genotypes of offspring: Ff, ff
    3. Phenotypes of offspring: 50% have freckles, 50% do not

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